Synthetic Biology at Genspace

May 23rd, 2012 by Corrie Van Sice | No Comments | Filed in Art & Design, Research, Science, Technique, Uncategorized

I’ve been attending Genspace’s Synthetic Biology courses lately, instructed by biologist Oliver Medvedik. Oliver assisted me in the past with my foray into mycelium culturing. In order to educated his students, Oliver shared some bacteria that express a set of genes coding for production of purple pigment. The operon called violacein was added to the BioBricks registry after a winning iGem team from Cambridge University presented their project E.Chromi in 2009. That team was directed by James King and Daisy Ginsberg.

BioBricks is essentially a kit of biological components for synthetic biology. I just wanted to say thanks to the community for the opportunity to hack your bio-code.

Transgenic Jell-O

August 19th, 2011 by Corrie Van Sice | No Comments | Filed in Research, Science

From NextNature:

jello marriage

Transgenic Jell-O, more human than ever!

The American Chemical Society has announced a new method of producing gelatin that sounds like good news for cannibals and the canni-curious. Researchers are able to create human-derived gelatin by inserting human genes for gelatin production into a strain of yeast. This new method would produce hypoallergenic, standard-sized molecules, two traits especially important for medical applications. Since the traditional method of producing gelatin from animal sources can very from batch to batch, provoke immune responses, and potentially carry diseases like Mad Cow, human gelatin is a step up in quality. We’ll admit that the human-yeast hybrid doesn’t really fall under any definition of actual cannibalism. But with the advent of lab-grown meat, there’s now less to stand in the way of adventurous eaters who want to create a real-life version of HuFu.

Via Discover Magazine. Image via Death and Taxes.

Swallowable Parfum

August 19th, 2011 by Corrie Van Sice | No Comments | Filed in Fashion, Research, Science

From NextNature:


Swallowable Parfum

Swallowable Parfum is a digestible scented capsule that works through your own perspiration. Once absorbed, fragrance molecules are excreted through the skin’s surface. A unique odor is emanated, depending on each individual’s acclimatization to temperatures, to stress, exercise, or sexual arousal.

This utterly intimate technology is being developed by body architect Lucy McRae in a collaboration with Harvard biologist Sheref Mansy.

The Secret of Creation Lies in the Wave

August 3rd, 2011 by Corrie Van Sice | No Comments | Filed in Art & Design, Research, Science
Diagrams and paintings by “outsider scientific-mystic” Walter Russell

Thanks to Yann for the tip

Will 50 Watts

Markus Kayser Builds a Solar-Powered 3D Printer that Prints Glass from Sand and a Sun-Powered Cutter

June 27th, 2011 by Corrie Van Sice | No Comments | Filed in Art & Design, Research, Science, Technique

from Colossal Art & Design

Markus Kayser Builds a Solar Powered 3D Printer that Prints Glass from Sand and a Sun Powered Cutter solar power printers design

Markus Kayser Builds a Solar Powered 3D Printer that Prints Glass from Sand and a Sun Powered Cutter solar power printers design

Markus Kayser Builds a Solar Powered 3D Printer that Prints Glass from Sand and a Sun Powered Cutter solar power printers design

Industrial designer and tinkerer Markus Kayser spent the better part of a year building and experimenting with two fantastic devices that harness the sun’s power in some of the world’s harshest climates. The first he calls a Sun Cutter, a low-tech light cutter that uses a large ball lens to focus the sun’s rays onto a surface that’s moved by a cam-guided system. As the surface moves under the magnified light it cuts 2D components like a laser. The project was tested for the first time in August 2010 in the Egyptian desert and Kayser used thin plywood to create the parts for a few pairs of pretty sweet shades. But he didn’t stop there.

Markus Kayser Builds a Solar Powered 3D Printer that Prints Glass from Sand and a Sun Powered Cutter solar power printers design

Markus Kayser Builds a Solar Powered 3D Printer that Prints Glass from Sand and a Sun Powered Cutter solar power printers design

Markus Kayser Builds a Solar Powered 3D Printer that Prints Glass from Sand and a Sun Powered Cutter solar power printers design

Markus Kayser Builds a Solar Powered 3D Printer that Prints Glass from Sand and a Sun Powered Cutter solar power printers design

Next, Kayser began to examine the process of 3D printing. Merging two of the deserts most abundant resources, nearly unlimited quantities of sand and sun, he created the Solar Sinter, a device that melts sand to create 3D objects out of glass. Via his web site:

This process of converting a powdery substance via a heating process into a solid form is known as sintering and has in recent years become a central process in design prototyping known as 3D printing or SLS (selective laser sintering). [...] By using the sun’s rays instead of a laser and sand instead of resins, I had the basis of an entirely new solar-powered machine and production process for making glass objects that taps into the abundant supplies of sun and sand to be found in the deserts of the world.

In mid-May the Solar Sinter was tested for a two week period in the deserts of Siwa, Egypt, resulting in the amazing footage above. It’s incredible to think that the solar energy generated for both machines is used only to power electronics, servos and the mechanism that tracks the sun, while the power used to cut wood and melt sand is just raw, concentrated sunlight. While I fully understand the mechanics and science at work in Kayser’s devices, there’s something about them that just seems magical. Definitely head over to his website to explore more photos and info. (via stellar, sorry can’t link the post for some reason)

Mycelium Structures @ Genspace/TerreformONE

June 13th, 2011 by Corrie Van Sice | No Comments | Filed in Art & Design, Research, Science

From my friends at Genspace:

There’s something about mushrooms that’s really great. It goes well with basically every kind of food out there as long as you cook them right (ever had mushroom sushi?), you can just throw some water at it and watch it grow like mushrooms, you can genetically engineer them into hulking monsters to do your bidding, and you can make up endless fun-guy jokes for as long as you work with them. No wonder one of our members decided it’s the perfect organism for an awesome collaboration project.

 

Our resident synthetic biologist, Oliver, had been hard at work with the guys at Terreform ONE for a while now. They were collaborating on a project to build large structures by using the mushroom growth as biomaterials that are cheap, modular, can be molded into any form, and remain lightweight and insulating.

First Oliver and the guys spent a week or do choosing different mushroom strains and figuring out how to grow them within laboratory settings, under controlled environment with different kinds of growth media. He went through a number of different mushrooms including shiitake, which didn’t make the cut and ended up on our pizza during one of Genspace meetings. Once he found the media, growth condition and mushroom strain of just the right kind of combination he disappeared for a couple of hours after which we found a strange structure on the third floor of the building, pictured on the left.

It’s an incubation-dry chamber complete with temperature&moisture control, recording devices for observation and documentation. What Oliver decided to do was to grow mushrooms within our incubation facility on the 7th floor and then send down completed mushroom-blocks in molds to the 3rd floor to be solidified and cast into true bio-bricks.

Oliver made bunch of prototype structures with the mushrooms and ended up building a model of the New Museum in preparation for an event called the Festival of Ideas for the New City, as a model of what the building of the future city might look like when built out of envrionmentally friendly materials that could be grown from the ground up.

The completed mushroom building prototypes of the New Museum, still in acrylic casts were then put on display at the evening of the festival for public eyes. Unfortunately the visitors couldn’t get a chance to find out what mushroom buildings would taste like.

The smaller mushroom buildings were complemented by a real 1/1 scale model of the New Museum built out of mushrooms, created by projecting time lapse video of the mushroom building that was in the incubation chamber onto the real New Museum building on Bowery street.


Kudos to Oliver and the people at Terreform ONE for creating what might be the first wholly mushroom based building in downtown Manhattan. Genspace is proud to have provided the space and some of the materials for such a collaborative effort, and I’m looking forward to even crazier arts and architecture collaborations between Genspace and other groups out there, maybe involving synthetic biology! Our doors are open to everyone, so if you think you have an interesting idea send us an email at any time to info at genspace dot org

Bre Pettis & MakerBot on Colbert Report

June 10th, 2011 by Corrie Van Sice | No Comments | Filed in Uncategorized

Designed Morphologies: Overview of Early Experiments

May 30th, 2011 by Corrie Van Sice | No Comments | Filed in Art & Design, Design Frontiers in Biology and Materiality, ITP, Research, Science, Technique

Designed Morphologies was presented to the public as part of the ITP Spring Show. Several experiments were on display, leading onlookers through problems addressed in the research and possibilities for the future.

How Nature Models:
Room Temperature, Room Pressure, Non-Toxic Materials, Material Conservation, Anisotropy, Fibers, Density

We look to “NATURE” for inspiration in ideals of beauty and harmony, often naively. Observing nature in the realm of fabrication is subject to some of the same idealism and error, yet scientists are looking beyond poetic abstractions to something much more fascinating — that is the question of how material comes together in the creation of elegant structural solutions to problems of strength and fitness. Some relevant issues at hand are the abilities of organisms to form materials at room temperature and pressure, using non-toxic ingredients in a resourceful manner. Getting metal, lumber and plastic into the variety of shapes that we design requires often enormous amounts of heat and pressure, and therefore enormous amounts of energy. Living organisms are more conservative with energy, and are capable of creating strong materials like bone, cartilage, tendon, shells, glass, bark and coral at the temperature and pressure of their natural habitat.

DEPOSIT
Material Mixes For a Powder Printer

Ease of use is perhaps one of the most significant factors for the success of rapid prototyping technologies. 3D printers create gorgeous renditions of digital models. The technology of plastic printers is advancing quickly, and recent versions allow for the printing of multiple materials in the same model — hard plastic can be deposited right next to a softer more flexible plastic. 3D powder printers, on the other hand, are capable of creating models in almost any medium that can be created from a powder and liquid component. There is enormous space for developing materials for powder printers which are generally less wasteful than their plastic extruding cousins, regardless of the current limitations in how many materials can be integrated in a single model.

In order to demonstrate the possibilities for future generations of powder printers, I set up a jig for manually printing in non-toxic powder and liquid media. The human powered printer works very similarly to commercial 3D printers: a roller spreads a thin layer of powder over a bed that is lowered in tiny increments as material is built up layer by layer. Simulating a print head that jets liquid binder over the powder in regions that will become a part of the final model, I created a stencil and misted liquid over each layer of powder. The first material tested is a cellulose-based resin, and even with this crude process, the printed model is quite strong. I am currently testing other materials, including starches and alginates.

AGGREGATE
Emulating Variation in Bone Density By Controlling Precipitation of Calcium Carbonate

Compact bone accounts for 80% of the total bone mass of an adult. The more porous cancellous, or spongy bone, accounts for only 20%, yet it has nearly ten times the surface area of compact bone. Using electrolysis, a method of creating chemical reactions by placing two ends of a power source into a medium, calcium carbonate can be accumulated in a controlled manner onto the cathode. Bone is made of of calcium phosphate, but calcium carbonate is a close cousin, collected by sea creatures to build strong shells.

The electrolytic process can help clarify how organisms control the formation of composite materials: bone and shells are made up of mostly minerals and only fractionally of proteins. DNA encodes for the production of these proteins which an organism uses as tiny magnets to direct the crystallization of inorganic minerals. Electrolysis demonstrates that calcium carbonate has an atomic structure that is attracted by a negative charge — a quality that underwater organisms use to structure their hard bodies.

Imagining electrolysis as a possible fabrication technology in itself, I aggregated calcium carbonate onto a designed structure, varying its density over time. Variation in density enables a conservation of materials while maintaining strong voluminous forms. The crystallization of calcium carbonate onto the cathode is influenced by several factors, primarily current. A higher current is capable of quickly precipitating CaCO3 out of a salt water environment, resulting in a light, spongy, and voluminous crystal structure, yet the material produced is very brittle. A lower current accumulates CaCO3 much more slowly, but its structure is more dense and less brittle. By varying the current circulating through the system, a structure with a light open interior and a dense exterior is produced.

By aggregating a material in this controlled way, it is possible to imagine a method by which objects can be fabricated with the same resourcefulness at which nature excels.

GROW
Culturing Mycelium as a Building Material: Growing the Glue

We are able to print organs by layering cells on top of one another in conjunction with nutrient layers, causing the cells to grow together into a unified entity. Material scientists use bio-engineering to isolate genes for the production of certain substances, like silk for instance. They put this gene inside of another very simple organism such as e.coli bacteria which becomes a machine for the generation the synthetic material. The use of living organisms in the production of new media means that materials can be cultured, laborers, alive, “born”, “killed”, and yet immediately intertwined with natural cycles of waste and renewal.

Designers Eben Bayer and Gavin McIntyre have popularized the use of mycelium to grow foam housing insulation and packaging. Being a very lightweight material, foam is of special interest beyond its protective qualities, especially if the waste created is compostable. Sculptors frequently carve objects from foam stock because of its portability and softness. Complex and curvy forms can be achieved, but regular high density foam, just like most plastics, is a by-product of petroleum. Heat forming polystyrene with hot wire cutters is especially noxious. By using plant matter like husks, oat bran and sawdust as the substrate for a compostable foam, dependency on a petroleum product is reduced and waste is easily bio-degraded.

Mycelium acts as a glue joining plant fibers together in a lightweight building material. The fungus replaces cellulose in the fibers as it grows. Here in NY I was privileged to have the help of Terreform One biologist Oliver Midvedik intern Dylan Butman who were very generous with their own research so that I might understand what the fungus needs to grow. I tested recipes for culturing mycelium within different substrates that produced changes in the consistency of the final foam product. I also created a silicone mold so that I could grow the material as a cast — directly replicating the desired shape without a need for further sculpting.

There are several limitations to culturing mycelium. Mushrooms tend to grow in anti-bacterial environments. The sap of trees especially has antibacterial properties, making wood and old logs a preferred medium for the growth of fungus. The cultures are easily contaminated, so great care is taken to keep the tools and media sterile: containers which are usually plastic, rubber or glass, are washed in a bleach bath and rubbed down with alcohol, the substrate is heated to kill unwanted bacteria and everything is handled with clean gloved hands. Over a period of about a week, a culture will turn the substrate into a beautiful creamy white block. The culture is then dried, killing the fungus and stopping its growth. With an understanding of the undesirable parts of this process, I am driven even further to address our dependence on plastic.

Alongside the experiments, visitors could look over a small library of texts and blog articles from experiment&play that connect computer aided design (CAD), bio-technology, synthetic biology, morphology, generative systems and design.

© 2011, Corrie Van Sice

Fiorenzo Omenetto: Silk, the ancient material of the future

May 29th, 2011 by Corrie Van Sice | No Comments | Filed in Research, Science, Technique

Fiorenzo Omenetto shares 20+ astonishing new uses for silk, one of nature’s most elegant materials — in transmitting light, improving sustainability, adding strength and making medical leaps and bounds. On stage, he shows a few intriguing items made of the versatile stuff.

Fiorenzo G. Omenetto’s research spans nonlinear optics, nanostructured materials (such as photonic crystals and photonic crystal fibers), biomaterials and biopolymer-based photonics. Most recently,… Full bio and more links

madMeshMaker from Golan Levin

May 23rd, 2011 by Corrie Van Sice | No Comments | Filed in Art & Design, Research, Technique

madMeshMaker_demoVideo from Madeline Gannon on Vimeo.

The madMeshMaker is a generative surface modeling environment created by Golan Levin’s Interactive Art and Computational Design course at Carnegie Mellon University, and has the intention to be an intuitive and fun introduction to fabrication with computer-numerically-controlled (CNC) table routers. CNC routers have become a staple of institutions related to digital design and manufacturing for their ability to rapidly fabricate models, furniture, interior systems, and other prototypical assemblages. However, because of the inherent 3D-modeling knowledge needed to both virtually and physically design, the machinery still remains an ‘advanced topic’ in academic curriculum. The madMeshMaker dissolves this notion, allowing any novice to digital technologies to easily create a virtual model embedded with the information necessary to communicate with a CNC router.

The application is intended to be distributed to freshmen architecture/design/art students, allowing them to rapidly explore and experiment with integrated digital design/fabrication technologies. With the madMeshMaker lowering the barriers-of-use, students are able to experiment more freely with the limits of what the fabrication technology can and cannot do … getting them to explore a surface through various materials, toolpaths, toolbit profiles, etc. By incorporating the application as a pedagogical tool in the beginning stages of their formal education, the goal of the madMeshMaker is to enable future designers to push beyond the conventional uses of the technology, and cultivate novel methods of design and production.

You can download the application from HERE

rapid designing+fabricating with the madMeshMaker from Madeline Gannon on Vimeo.